Exploring the toxicology and pathobiology of the lung using cellular and molecular approaches
About the lab:
We study the effects of environmental pollution on the lung. In particular, we are interested in how exposure to lung toxicants leads to lung disease andalters normal lung biology. Pollutants under investigation include: ozone, allergens, tobacco smoke, particulate matter, bisphenol A and polycyclic aromatic hydrocarbons, such as naphthalene. We train undergraduate, graduate and postdoctoral students in lung pathobiology, toxicology and research. We contribute to UC Davis specialized research facilities as the supervising laboratory for the Cellular and Molecular Imaging (CAMI) core. A weekly journal club is held throughout the year for graduate students from multiple labs and graduate programs.
The Van Winkle Lab is primarily housed in the Cell Biology Building (Room 514, 517, and 519) of the Center for Health and the Environment (CHE). This building has laboratories that are designed and equipped for tissue culture. Air flow in the building is designed to provide positive pressure in the laboratory and, thereby, reduce the risk of outside contamination. This also makes this building a perfect site for microscopy equipment, so this is where the CAMI core is located (Room 514). We also have a histochemistry lab equipped for immunohistochemistry and resin embedding (Room 106) and share a fixation and tissue processing lab at the Toxic Pollutant Health Research Lab (TPHRL) also located at CHE. TPHRL contains inhalation exposure facilities that can be used to study environmental tobacco smoke, combustion-generated particles, incidental and engineered nanomaterials, concentrated ambient particles, and electronic nicotine delivery systems (ENDS), such as electronic cigarettes, mods, and tanks.